Beilstein J. Org. Chem.2022,18, 1707–1719, doi:10.3762/bjoc.18.181
group on C6 was introduced after cyclopropane ring-opening, ketone protection, epoxidation and reductive ring-opening of the resulting epoxide. A one-pot β-keto phosphonateformation/Horner–Wadsworth–Emmons reaction with formaldehyde afforded 38, a precursor for the key oxidative dearomatization-induced
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Graphical Abstract
Figure 1:
General structure of grayanane natural products.
Beilstein J. Org. Chem.2014,10, 1645–1650, doi:10.3762/bjoc.10.171
no activity against FDPS even at a 10 μM concentration.
Keywords: bisphosphonate; isoprenoid biosynthesis; organophosphorous; phosphonateformation; Introduction
Several enzymes of the isoprenoid biosynthesis pathways are the targets of widely prescribed drugs. For example, hydroxymethylglutaryl